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Visiting Scholars  Rick HorwitzUniversity of Virginia Website "Rick" Horwitz is the Harrison Distinguished Professor of Cell Biology at the University of Virginia School of Medicine and Director of the Cell Migration Consortium. He trained in chemistry, biophysics and magnetic resonance at UW Madison, (BA), Stanford, (PhD) and UC Berkeley (post doc). However, his interests quickly turned to cell adhesion and then to cell migration, areas that he helped to pioneer. Prior to his appointment at UVa, he was a professor in the Department of Biophysics and Biochemistry at the University of Pennsylvania, School of Medicine and Head of the Department of Cell and Structural Biology at the University of Illinois. His present research interests include adhesion and cytoskeletal function, organization and regulation during migration, the mechanism of dendritic spine morphogenesis and synapse formation in hippocampal neurons, and the development and use of quantitative imaging modalities. Throughout his entire career, he has tried to work at the vanguard of emerging disciplines using cutting edge technologies. In addition to his research activities, he has served in numerous capacities to advance his field and discipline.  David WeitzHarvard University Website David Weitz received his PhD from Harvard and then worked as a research at Exxon Research and Engineering before going the University of Pennsylvania as a Professor of Physics. He moved to Harvard in 1999, where he is Professor of Physics and Applied Physics. He is also the director of Harvard's NSF-funded Materials Research Science and Engineering Center, and is co-director of the Kavli Institute for Bionano Science and Technology at Harvard. He was instrumental in founding the BASF Advanced Research Initiative at Harvard, which he currently co-directs. Weitz's research group works on experimental soft matter science. They study a broad range of systems, with considerable focus on mechanics and rheology. They have a large effort to study the mechanics of biopolymer networks of reconstituted proteins, and have applied the methodology developed there to investigate the mechanics of cells and their interactions with the surrounding matrix. They also have a large effort in applications of microfluidics to high throughput screen applications in biology and biotechnology.  Andrew MurrayHarvard University Website Andrew Murray received his B.A. in biochemistry from Clare College, University of Cambridge (UK). For his Ph.D., with Jack Szostak at Harvard Medical School, Murray constructed artificial chromosomes in yeast. In his postdoctoral work with Mark Kirschner, at the University of California, San Francisco (UCSF), Murray showed that the synthesis and destruction of a protein called cyclin regulates the cell division cycle. From 1989 to 2000, Murray was on the faculty of the Physiology department at UCSF. Since coming to Harvard in July 2000, he has been a professor in the Molecular and Cellular Biology department and Director of the Bauer Fellows Program. His group works on three subjects using the budding yeast, Saccharomyces cerevisiae: 1) chromosome behavior during mitosis and meiosis, 2) mating, and 3) experimental evolution. His group trys to make quantitative measurements that discriminate amongst different classes of models and its members come from both biology and physics backgrounds. He uses genetic and physiological perturbations to try to understand the “rules of the game” that explain how cells reproduce, respond to their environment, and evolve. Murray is co-author, with Tim Hunt, of The Cell Cycle: An Introduction (Oxford University Press). He is a Fellow of the American Academy of Arts and Sciences. Recent publications: Leu, J-Y. and Murray, A.W. 2006. Experimental Evolution of Mating Discrimination in Budding Yeast. Curr. Biol. 16, 280-286. Palframan, W.J., Meehl, J.B., Jasperson, S.L., Winey, M., and Murray, A.W. 2006. Anaphase Inactiviation of the Spindle Checkpoint. Science, 313. 680 - 684. Thompson, D.A., Desai, M.M., and Murray, A.W. 2006. Ploidy Controls the Success of Mutators and Nature of Mutations During Budding Yeast Evolution. Curr. Biol., 16, 1581-1590. Desai, M.M., Fisher, D.S., and Murray, A.W. 2007 The Speed of Evolution and Maintenance of Variation in Asexual Populations. Curr. Biol. 17, 385-94. Ingolia, N. and Murray, A.W. 2007. Positive Feedback Loops as a Flexible Biological Module. Curr. Biol., 17, 668-77. Lacefield Shimoda, S. and Murray, A.W. 2007. The spindle checkpoint rescues the meiotic segregation of chromosomes whose crossovers are far from the centromere. Nature Cell Biol. 39, 1273-7. Indjeian, V. and Murray, A.W. 2007. Budding Yeast Mitotic Chromosomes Have an Intrinsic Bias to Bi-Orient on the Spindle. Current Biology, 17, 1837-46. Lang, G. I. and Murray, A. W. 2008. Estimating the per-base-pair mutation rate in the yeast, Saccharomyces cerevisiae. Genetics,178, 67-82. |
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